A Teen's ADHD
Doesn't End

when the school day does.

Consider a treatment that lasts up to 16 hours post-dose measured from 2 hours.1

MYDAYIS® is the first and only triple-bead mixed amphetamine salts (MAS) formulation that may help with improved attention, with once-daily dosing.1

Primary Endpoint1: In Study 5, patients aged 13-17 treated with Mydayis experienced significant improvement in attention vs placebo based on LS mean PERMP total scores up to 16 h post-dose, measured from 2 h post-dose.

WHY MYDAYIS

TRIPLE-BEAD DELIVERY

for prolonged release

For over 20 years, Shire has been committed to ADHD research to help meet the needs of adolescent patients. Mydayis is the first ADHD treatment to use triple-bead delivery for extended release of MAS medication through the morning, afternoon, and evening.1

Immediate-release

First Bead:
Immediate-release
Immediate release in the stomach

Delayed-release (DR-1)

Second Bead:
Delayed-release (DR-1)
Release at pH 5.5

Delayed-release (DR-2)

Third Bead:
Delayed-release (DR-2)
Release at pH 7.0

Beads shown are not actual size or color.

Three types of beads in a single capsule release at different pH levels for prolonged amphetamine delivery.1

See how it works

better attention

Up to 16 hours

post-dose, measured from 2 hours,
vs placebo in patients aged 13-17 as evaluated by PERMP1

IMPORTANT SAFETY INFORMATION (continued)

Contraindications

  • Known hypersensitivity to amphetamines or other ingredients of Mydayis. Angioedema and anaphylactic reactions have been reported with other amphetamines.
  • Use with monoamine oxidase inhibitors (MAOIs) or within 14 days of last MAOI dose, due to increased risk of hypertensive crisis.

PRIMARY ENDPOINT: Adolescent patients receiving Mydayis 25 mg demonstrated significant improvement in attention compared with placebo on PERMP total score measured from 2 hours and continuing up to 16 hours post-dose.1 The post-dose average score over all testing sessions was 256 for Mydayis and 215 for placebo (P<0.0001).2

Adolescent (aged 13-17) patients receiving Mydayis demonstrated significant improvement in attention vs placebo, from 2 to 16 hours post-dose

PERMP Attention in ADHD was measured using the Permanent Product Measure of Performance (PERMP), which is a skill-adjusted math test. The PERMP score is the sum of the number of math problems attempted plus the number of math problems answered correctly in a 10-minute session. Higher scores indicate better attention.1,2

Patients can

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*Eligibility and restrictions apply.

References
  1. Mydayis [package insert]. Lexington, MA; Shire US Inc.
  2. Data on file; SPD465-202; Shire US Inc.